April 22 - Battle of Bicocca - French and Swiss forces under Odet de Lautrec are defeated by the Spanish in their attempt to retake Milan, and are forced to withdraw into Venetian territory.
September 6 - The Vittoria, one of the surviving ships of Ferdinand Magellan's expedition, returns to Sanlcar de Barrameda in Spain, becoming the first ship to circumnavigate the world.
December 18 - The Turks finally break into Rhodes, but the Knights continue fierce resistance in the streets