April 22 - Treaty of Saragossa divides the western hemisphere between Spain and Portugal that the dividing line should lay 297.5 leagues west of the Moluccas. Spain gets monetary compensation in return for giving Portugal more territory that was in the earlier treaty.
October 15 - With the season growing late, Suleiman abandons the siege.
Emperor Charles V and Francis I of France sign the Treaty of Cambrai, or the "Ladies' Peace". Francis abandons his claims in Italy, but is allowed to retain Burgundy.
Thomas Wolsey, Archbishop of York, fails to bring about the divorce and annulment Henry VIII had sought and is forced to resign.