The Isotopes began playing in 2003 when the Calgary Cannons relocated to New Mexico. Their major league affiliation is the Florida Marlins.
The name was chosen by the fans in the city, taking the name from an episode of The Simpsons where Homer's favorite team, the Springfield Isotopes, threatened to move to Albuquerque.
After the Dukes relocated, the city of Albuquerque almost completely destroyed the team's home stadium, Albuquerque Sports Stadium, but kept the old playing field intact. The city then built a completely new stadium around the existing field. The new venue opened in 2003 as Isotopes Park.