She was born in the College, Youghal, County Cork, Ireland. On July 21, 1631 she married David Barry (Son of Lord William Barry of Olethan) 1st Earl of Barrymore when she was 24 and he was 26.
She had two children from that marriage:
About two years after David Barry's death, Lady Alice married again. Her second husband was John Barry, the younger brother of her first husband David.
Lady Alice had no children by this second marriage. She is buried in Youghal, County Cork, Ireland.