The amen break in its different forms - looped straight as in old-skool drum and bass or totally cut up and rearranged as in some tunes by artists like Squarepusher and Amen Andrews - is used in literally thousands of drum & bass songs and in noticeably many hip-hop tunes also.
Amen break's popularity probably lies in both the rough, funky, compressed style the drums are recorded in and the swing and the groove of the drummer that plays the solo. The original song is also quite fast, which probably made it so popular among the old-skool drum and bass artists.