Typically, the wild-card team plays the division leader with the best winning percentage in one series, and the other two division leaders play the other series. However, if the wild-card team and winningest division leader are from the same division, the wild-card team plays the next winningest division leader, and the other two division leaders play. In any event, the two series winners move on to the best-of-seven ALCS.
Since the ALDS's inception, the only teams to meet more than twice are the Cleveland Indians vs. the Boston Red Sox, the Seattle Mariners vs. the New York Yankees, and the Texas Rangers vs. the New York Yankees.