Use of water from the Amu Darya for irrigation has been a major contributing factor in the shrinking of the Aral Sea since the late 1950s.
In antiquity the river was known as the Oxus, and historical records tell that during the history the Oxus has flowed to all of the Aral Sea, to the Caspian Sea, or both, similarly to the Jaxartes river.
see also Syr Darya, Transoxania