Berrios was defeated in the 1976 elections by PNP (New Progressist Party or Partido Nuevo Progresista) candidate Miguel Hernandez, but he came back on top during the 1980 elections. After being sworn back to office in 1981, he began a period of 12 years in a row as mayor of Caguas. During his tenure, new hospitals, malls, department stores and housing complexes were built.
Berrios in 1987 became the managing owner of the Criollos BSN basketball team, and later on, he acquired the Criollas women's superior volleyball team.
Berrios decided not to run for mayor again in 1992, being substituted by William Miranda Marin as PPD leader in Caguas. Miranda Marin went on to win the elections that year.
Later on, an entertainment center was named after Berrios, the Centro de Bellas Artes Angel O. Berrios.