She wrote the books Comet and Shadows of Forgotten Ancestors, as well as sections of The Demon-Haunted World, with her late husband Carl Sagan. In addition, she wrote an introduction to The Cosmic Connection and the epilogue to Billions and Billions, both by Sagan. Alone, she wrote the novel A Famous Broken Heart.
In the areas of film and television, she was one of the writers for the television series Cosmos, and a producer of the film Contact. Most recently, she is the CEO and a co-founder of Cosmos Studios.
Other projects that she has been involved in include the selection of the music on the record on the Voyager 1 and Voyager 2 space probes, and the Cosmos 1 spacecraft which will demonstrate solar sail propulsion.