Until recently, Anna's did not live a secluded life. When already a few months old, she posed with her mother for an ad campaign. Later, she did her first extra role in the movie Uncle Buck (1989).
Her big breakthrough was the box-office hit My Girl, in which she played the leading part. Anna also appeared in the less popular sequel My Girl 2, Trading Mom.
She is also one of the few actresses who can say that she has played a leading part with a U.S. President in office, namely Bill Clinton.