Anne was descended from King Edward through one of his older sons, Lionel of Antwerp, which gave her a claim on the throne after the death of her father and siblings. In about 1406, she married Richard, Earl of Cambridge, who was also descended from Edward III through a younger son. They had two children, Isabella and Richard, who later laid claim on the throne, beginning the Wars of the Roses. It is believed that Anne died giving birth to him.