Lugosi's character tries to create an army of supermen to do his bidding but is thwarted by the good guys. The film's highlight is when Bela is thrown atop a rubber octopus and moves its arms in the vain attempt to simulate animation on the part of the beast. Previous splices of a live octopus in a fish tank with the rubber octopus do nothing to make it seem more realistic.
The television program Mystery Science Theater 3000 featured Bride of the Monster in one episode. The shooting of this movie is also re-enacted in Tim Burton's biopic of Wood, including a sequence showing Wood (played by Johnny Depp) and his crew stealing the phony octopus from a props storage vault.
Arguably this film's most memorable line is spoken by Lugosi's character: "One is always considered mad, if one discovers something that others can not grasp". It has been argued by commentators on the film that it is actually meaningful as a criticism of standard views and ideas. It has also been suggested that the phrase expresses both Wood's and Lugosi's bitterness at the lack of appreciation for their work.
According to Leonard Maltin's Movie and Video Guide, Bride of the Monster remained unreleased for 23 years because Wood could not pay his film processing bill.