It is a one-way street only allowing vehicular traffic to travel northwards (southbound traffic uses the parallel Camden Street).
Travelling north, traffic emerges from Hampstead Road (A400) into the High Street at the junction with Eversholt Street, by Mornington Crescent tube station.
The northern extremity of Camden High Street lies just north of the five-way junction formed with Parkway, the southern end of Chalk Farm Road, Kentish Town Road (where the A400 continues) and Camden Road. Camden Town tube station is on the corner between Camden High Street and Kentish Town Road.