She was born at Carlton House in London, her birth being something of a miracle as George IV later claimed that he and his wife had sex no more than three times in the whole of their marriage. By the time she was a few months old, her parents were effectively separated, and her mother's time with her was severely restricted by her father, who doted on the child. She grew into a headstrong and difficult teenager, and fell out with her mother when Caroline decided to go into continental exile.
Charlotte married Prince Leopold of Saxe-Coburg on May 2 1816, also at Carlton House. After a miscarriage in the early months of their marriage, she delivered a stillborn son on November 5, 1817, dying of post-partum complications the next day. She is buried in St George's Chapel, Windsor. Her death, which left the Prince of Wales without any direct heirs, resulted in a mad dash towards matrimony by most of her bachelor uncles. Her father, even after the death of his wife, made no attempt to remarry or father any more children.