In 1774, a group of settlers, including Colonel Michael Cresap and Daniel Greathouse, murdered many of the local peoples, including all of Logan's family. Logan was infuriated, and believed that the Americans pouring in to his tribal lands posed an imminent danger to his people. He responded by attacking their settlements along the Monongahela River. He and his Shawnee ally Cornstalk were eventually defeated at the Battle of Point Pleasant, and the Native American peoples of the region were forced to surrender their land claims in Kentucky. While Cornstalk agreed to the surrender, Logan refused to attend. Instead, he issued a speech, describing how he had befriended the Europeans and helped them settle the region, but rather than receive any thanks, he saw his family murdered. Having seen his entire family murdered, he ended with the chilling statement: "Who is there to mourn for Logan? No one."
For several years, Logan continued to attack the settlers invading the Indian territories. He was murdered (possibly by a nephew) in 1780.