The village name comes in two parts: the former name 'Clifton' is Anglo Saxon in origin and means 'Cliff farm', referring to the village's position on a cliff on a bank of the River Ouse. The latter name 'Reynes' refers to the ancient lords of the manor of the village, whose family name this was. In the Domesday Book on 1086 Clifton Reynes was recorded as Cliftone.