There are several types of disabilities that impact computer use:
About 10% of people suffer from some form of colorblindness. In a well-designed user interface, color should not be the only way of distinguishing between different pieces of information.
Some people may not be able to use one of the input devices, the mouse or the keyboard. Therefore it is important for software functions to be accessible using both of them. Keyboard shortcuts and mouse gestures are ways to achieve this. More specialized solutions like on-screen keyboards and alternate input devices like joysticks and trackballs are also available.
The astrophysicist Stephen Hawking is a famous example of a person suffering from motor disability. He uses special software that allows him to control his computer using the movement of only two fingers.