It is produced by the hypothalamus and stimulates corticotropic cells of the anterior lobe of the pituitary to production of ACTH and other biologically active substances (for example β-endorphin). CRH is also synthesized by the placenta and seems to determine the duration of pregnancy.
The sequence of amino acid residues was first determined by Shibahara in 1983.
Ser - Glu - Glu - Pro - Pro - Ile - Ser - Leu - Asp - Leu - Thr - Phe - His - Leu - Leu - Arg - Glu - Val - Leu - Glu - Met - Ala - Arg - Ala - Glu - Gln - Leu - Ala - Gln - Gln - Ala - His - Ser - Asn - Arg - Lys - Leu - Met - Glu - Ile - IleNH2
See also: