There are three different versions of the Desert Eagle: the Mark I, Mark VII, and Mark XIX. The Mark I is no longer produced, but was available in .357 Magnum and .44 Magnum. The Mark VII is currently available in .44 Magnum, with .357 Magnum and .41 Magnum chamberings no longer being produced. The most recent, the Mark XIX, is available in .357 Magnum, .44 Magnum, and .50 Action Express.
Switching a Desert Eagle to another chambering requires only that the correct barrel be installed. Thus, owners only need to buy a different barrel to shoot the other cartridges. The most popular barrel length is 6", although 10" barrels (which are rarely seen) are also available.
It is fed with a detachable box magazine, just as with any other semi-auto pistol. Because it fires such large cartridges, magazine capacity is limited to a meager nine rounds in .357 Magnum, 8 rounds in .44 Magnum, and 7 rounds in .50 Action Express. Compare this to the full-sized service type pistol, the SIG-Sauer P226 (which is smaller and lighter), when chambered in 9mm Luger it can have normal magazine capacities of up to sixteen rounds. You can immediately discern that the Desert Eagle is best suited for sporting purposes and is not a practical service weapon (despite Hollywood's portrayal of it otherwise) because of its extremely large size, weight, and the difficulty for the average person to handle the punishing recoil of the large cartridges it fires.