In form, a Dewar flask is a glass bottle, with a double-layer construction; in fact, it can be considered to be two thin-walled bottles nested one inside the other, and sealed together at the neck. The narrow space between is evacuated almost entirely of air; the near vacuum prevents conduction of heat.
The inner surface of the outer bottle, and the outer surface of the inner bottle, have a metallic or similar reflective coating to prevent heat from being transmitted via radiation. This is so effective that what little heat transport does occur is almost entirely via the neck and stopper; insulating materials such as cork are often used for the stopper.
A very common use of the Dewar flask in laboratories is the storage of liquid nitrogen; in this case, the leakage of heat into the extremely cold interior of the bottle results in a slow 'boiling-off' of the liquid (a valve is provided to prevent pressure from building up). The excellent insulation of the Dewar flask results in a very slow 'boil' and thus the nitrogen lasts a long time without the need for expensive refrigeration equipment.
A 'Thermos bottle' (trademarked), or vacuum flask (generic) used to keep coffee or other beverages hot, is sometimes based on a Dewar flask; since the glass flask is fragile and somewhat expensive to fabricate, other constructions based on plastic or insulated metal are also popular.