Ho released his debut album, Don Ho Show, in 1965 and began to play high profile locations in Las Vegas, Lake Tahoe, and New York. In 1966, he released his second album, a live compilation called Don Ho -- Again!, which charted in the early part of 1966. In the fall of 1966, Ho released his most famous song, "Tiny Bubbles", which charted on both the pop and easy listening charts and caused the subsequent Tiny Bubbles LP to reach the album Top 20 for almost a year. Guest appearances on television shows such as The Brady Bunch soon followed. Although his album sales peaked in the late 1960s, he was able to land a television spot on ABC from October 1976 to March 1977 with the Don Ho Show variety program.
Don Ho continues to be a popular concert tour draw among fans of all ages. He still performs regularly at the Waikiki Beachcomber Hotel. He also can be seen at the restaurant/night club that he owns called "Don Ho's Island Grill," in downtown Honolulu near Aloha Tower.
Ho's daughter, Hoku, performed with her father in his Waikiki show and later went on to become a nationally known recording artist in her own right.