Several years later, in 1907, she was drawn to the cause of helping people with tuberculosis. She had already heard of an idea in Denmark in which people attached a special stamp to their mail, the proceeds of which would go to fight the disease, and decided to introduce the same idea in Delaware. Her goal was to raise $300 dollars for a local sanitorium, using a bright red stamp she designed herself, and convinced local post offices to sell them for just 1 cent. This way, she believed, even the poorest people could help in the fight against TB.
Though the idea failed at first, Bissell was able to gain enough publicity from a Philadelphia newspaper to make $3,000, ten times the amount she originally hoped to get. People were intrigued by the idea of Christmas seals, and the following year, Howard Pyle, a leading illustrator donated the design of the second stamp.
Bissell spent the remainder of her life promoting Christmas stamps and helping to eliminate tuberculosis. She died in 1948. There is still a hospital in Wilmington that bears her name.