He was sent on various missions to persons of high rank, amongst them Pope Innocent VIII, by whom he was nominated to the important office of patriarch of Aquileia (1491). The Venetian senate, however, refused to ratify the appointment, which, contrary to the law, he had accepted without first obtaining its sanction. He was banished and forced to resign the patriarchate, under the threat of being punished vicariously by the confiscation of his father’s property. Barbarus remained at Rome, in receipt of a small pension from the pontifical government, until his death (probably from the plague) on the 14th of June 1493 (according to some, two years later).