From January 22 to March 7, 1914 he was the Chairman of the Central Administration.
Alizoti was Minister of Finances of Albania in 1918–1920, 1927 and during the Italian occupation in Shefqet Verlaci's government from April 12, 1939 to 1940.
When Italy had conquered a big part of Yugoslavia, in June 29, 1941, Mussolini decided to hand over to Albania the ethnic-Albanian inhabited areas on the Yugoslavian territory under Italian occupation: most of the province of Kosovo, the western Macedonia (the districts of Tetovo, Gostivar, Kichevo, Debar and Struga) and a small part of Montenegro. Alizoti was appointed the High Commissioner (civil governor) of those areas. He demanded that they would become ethnically homogeneous, inhabited only by ethnic Albanians. Alizoti occupied that post until those areas were formally annexed to Albania on December 3, 1941.