After failed attempts to become a playwright, he penned the novel The Mystery of a Hansom Cab (1886), which became a great success after he self-published. He sold the English and American rights to the novel for fifty pounds, and thus derived little benefit from its success.
After the success of his first novel, Hume returned to England. He resided in London for few years and then he moved to the Essex countryside where he lived in Thundersley for thirty years, eventually producing over 100 novels and short stories.