Meza was cast by Chespirito to play Dona Florinda in the Televisa comedy show El Chavo Del Ocho, which became a major international hit. Playing Dona Florinda (and Popis), Florinda Meza became known all over Latin America. The show lasted from 1970 to 1978, era during which she and Chespirito got married. After production of the show was finished, she and her husband began touring extensively, something they still do. Chespirito and Florinda Meza have faced trouble at certain countries they have been to, hotel workers and others accusing them of behaving like a diva and divo, respectively.
Meza also participated in several movies, and she directed telenovelas such as La Duena (The Owner) and Milagro y magia (Miracle and Magic).
Meza also participated prominently in Chespirito's other main show, El Chapulin Colorado.