Fountain of Dreams is set in post-nuclear-war Florida, literally separated from the continental United States due to heavy bombing. Life on the island of Florida is constantly threatened by the threat of mutation (due to residual radiation) and encounters with local ruffians known as the Killer Clowns as well as three oranized crime factions, the DeSoto Family, the Obeah Orders, and the Bahia Mafia.
Players control a small band of adventurers who set out to find the purifying waters of the legendary "Fountain of Dreams" to stop the spread of mutation.