Upritchard was born in New Zealand and studied there at the University of Canterbury. She eventually moved to England, and as of 2003 is based in London.
In 2003, Upritchard was shortlisted for the Beck's Futures prize. For the prize exhibition she made Save Yourself, a small mummy surrounded by funerary urns which lies on the gallery floor vibrating and moaning. A packet of cigarettes is tucked into its bandages, and a single glass eye can also be seen.
Upritchard has also showed drawings, diagrams and notes associating Prince Charles with the beast from the Book of Revelation.