Leighton received his artistic training on the European continent, first from Edward von Steinle and then from Giovanni Costa. He lived in in Paris from 1855 to 1859, where he met Ingres, Delacroix, Corot, and Millet. In 1860, he moved to London, where he associated with the Pre-Raphaelites. In 1864 he became an associate of the Royal Academy and in 1878 he became President of the Royal Academy.
His house in Holland Park, London has been turned into a museum, the Leighton House Museum. It contains a number of his drawings and paintings.
His work includes: