The world of Fusion is centuries in our future, when a series of galactic wars have led to a spiraling arms race between "tekkers and splicers". That is to say those who take a technological and technocratic route to improving humanity, and those who have abandoned humanity altoghether through genetical engineering. The story involves the exploits of a group of space mercenaries in an era when humans who have not been enhanced either genetically or cybernetically, are becoming extremely rare.
;Indio Tremaine:Captain. Human. Born into the clan of the three suns, she is the only survivor of her clan.
;Dow Cook:Synthetic human with juiced up self-healing ability. Very insecure about himself.
;Tan:A musteliform bred from Terran otter stock. Canadian, an alumni of Labatts Tech. An alcoholic mechanical and electronics wizard with a severe gambling problem. Never goes anywhere without his leather pilot cap and goggles.
;Beolvoch:A meehook. Something like a dinosaur with fur. Has a voracious appetite for raw meat. Must eat regularly and copiously to keep his metabolism up. Consequently sends much time in a suspended animation state or complaining that he is hungry. Appears to be a genuine alien species rather than uplifted and genetically engineered earthform.
;Alshain:A felinoid; a temperamental and somewhat edgy pilot.
;Carz:A leoniform veteran with only one working eye. He is generally a steadying influence, but when he loses it, beware!
;Herrick:A hawklike creature, of military caste. Dies very early in the series in one of many moves which went against formula in the series. Appears in "how we got here" sequences.
;Haven:An birdlike creature with well developed nesting instincts. She is a doctor by training.
;Eddie:Modelled after some creature with very long ears and a prehensile tail. Likes to hang upside down. A cool dude in shades and khakis or hawaaian shirts. Nothing rattles Eddie. Was a class-mate of Tan at Labatts tech. (Australian?)
Regular characters
The only recurring characters are the crew of the mercenary spaceship Tsunami.
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