He was preceded in office by Peyton Randolph and succeeded first by Peyton Randolph for a few days, then by John Hancock.
While a delegate to the Continental Congress, he resigned in order to prepare for the coming war. He was replace by his son Arthur Middleton (1742-1787), who went on to sign the Declaration of Independence and the Articles of Confederation.
Arthur's son, also a Henry (1770-1846), had a long career in politics. He was Governor of South Carolina (1810-1812), U.S. Representative (1815-1819), and the Minister to Russia (1820-1830).