Enterprize was recommissioned in 1756 at the outbreak of the Seven Years' War, again for service in the West Indies and North America and resuming her duties as Atlantic convoy escort. In 1762 she was present at the siege and capture of Havana, Cuba, an action involving nearly 60 warships and transports enough for more than 16,000 troops.
Enterprize was decommissioned in January 1764 and was broken up in 1771 at Sheerness.
See HMS Enterprise for other Navy ships of this name.