The word, however, was used long before Shakespeare used it in Love's Labour Lost, and thus the anagram stands as proof of the anti-Stratfordians' ingenuity rather than as a marker of authorship.
Honorificabilitudo appears in a Latin charter of 1187, and occurs as honorificabilitudinitas in 1300. Dante cites honorificabilitudinitate as a typical example of a long word in De Vulg. Eloq. II. vii. It also occurs in the Complaynt of Scotland, and in Marston's Dutch Courtezan (1605).
The earliest use listed in the Oxford English Dictionary is 1599, by Nashe: "Physitions deafen our eares with the Honorificabilitudinitatibus of their heauenly Panachaea, their soueraign Guiacum."