Dorough participated in the Orlando production of The Wizard Of Oz to get his start in show business.
He later auditioned for The Backstreet Boys, where he reached worldwide fame along with group mates AJ McLean, Brian Litrell, Kevin Richardson and Nick Carter. After the group reached stardom, Dorough and the rest of the band became staples on the covers of such magazines as tiger Beat, 16 (magazine), Teen Beat, etc etc.
Howie had a sister, Caroline Dorough, who sadly passed away of the Lupus form of Cancer. After her passing, Howie helped create The Dorough Lupus Foundation, where he still collaborates.