Number of Miles 941 miles Louisiana - 64 miles Mississippi - 290.494 miles Tennessee - 12 miles Arkansas - 73 miles Missouri - 209 miles Illinois - 293 miles Major Cities Along the Route New Orleans, Louisiana Jackson, Mississippi Memphis, Tennessee Saint Louis, Missouri Chicago, Illinois Intersections with other Interstates Interstate 10 in La Place, Louisiana Interstate 12 in Hammond, Louisiana Interstate 20 in Jackson, Mississippi Interstate 40 in Memphis, Tennessee Interstate 57 in Miner, Missouri Interstate 44 in Saint Louis, Missouri Interstate 64 in Saint Louis, Missouri Interstate 70 in Saint Louis, Missouri. They stay joined until an exit near Troy, Illinois. Interstate 72 in Springfield, Illinois Interstate 74 in Normal, Illinois Interstate 39 in Normal, Illinois Interstate 80 in Shorewood, Illinois Interstate 90 in Chicago, Illinois Interstate 94 in Chicago, Illinois Spur Routes Caruthersville, Missouri - I-155 Saint Louis, Missouri - I-255 Spur to Peoria, Illinois - I-155 Chicago, Illinois - I-355 Notes