Ira Losco started her musical career in 1997 as a member of a band called Tiara. They performed in clubs in the Paceville area, the musical area of Malta. They were voted best band at the Student Festival of 1999.
In 2000 Ira Losco made her first steps in showbusiness as a solo singer. She participated in the national preselections for the Eurovision Song Contest with two songs. This resulted in appearances in many tv-shows. She played one of the main roles in a Maltes musical called Rita. In 2001 she participated in the national selections for Eurovision again, now being the runner-up behind Fabrizio Faniello.
Ira participated in several festivals and was voted "Best Female Singer" at the Malta Music Awards 2001. In 2002 she represented Malta in the Eurovision Song Contest. After a close run with Latvia she finally got a second place, the best score ever for Malta with her song 7th wonder.