Reed was born in Chattanooga, Tennessee, grew up in Buffalo, New York (where he attended the University of Buffalo), lived in New York City in the 1960s, and currently lives in Oakland, California, where he teaches at the University of California, Berkeley.
Reed's best-known works include The Free-Lance Pallbearers (1967, Reed's first novel), Mumbo Jumbo (1972), Flight to Canada (1976), and The Last Days of Louisiana Red (1974). He has published more than a dozen books, including seven novels, four collections of poetry, and two collections of essays.