The movie catapulted young Jackie into superstardom. He began a long on-screen relationship with actor Wallace Beery in such films as The Champ (1931), The Bowery (1933), Treasure Island (1934), and O'Shaughnessy's Boy (1935).
Cooper had problems finding roles as he became an adolescent, and he served in World War II, so his career was at a nadir when he starred in two popular television series, The People's Choice and Hennesey. It was his television acting that convinced him that he could become a director, and he successfully moved behind the camera, to become one of the busier television directors, for which he won Emmy Awards.
Later in the 1970s, he found renewed fame as Clark Kent's editor, Perry White, in the Superman feature film series starring Christopher Reeve.
His autobiography, Please Don't Shoot My Dog, was published in 1981. The title comes from Norman Taurog's threat to shoot young Jackie's dog if he couldn't cry in Skippy.
Cooper has a star on the Hollywood Walk of Fame at 1501 Vine Street.