Inspired by Laila Ali's participation in the sport and eager to avenge the losses her father suffered at the hands of Ali's father, Muhammad Ali in two of their three fights, Frazier-Lyde began her career on February 6 of that year, knocking out Teela Reese in one round. Eventually, she and Ali kept on winning. Laila was 8-0 and Jackie 7-0 with 5 knockouts when they starred on the first Pay Per View boxing card ever to be headlined by women. The bout, nicknamed Ali-Frazier IV by the media, in allusion to their legendary fathers' trilogy, was boxed on June 8 of 2001 to headline the weekend activities of the International Boxing Hall Of Fame induction ceremonies. Ali won on an eight round decision, and Frazier-Lyde started clamoring for a rematch.
Frazier-Lyde has gone on with boxing after that, winning two more fights. She was recently challenged by one of her contenders to a fight while she was in a New York ring to receive a plaque for her father during a charity activity.
Frazier-Lyde has a record of 9 wins, 1 loss and 7 wins by knockout.