In 1791, he moved to London and set up his own engineering business, having by then begun to expand into civil engineering. His early projects included the Lancaster Canal (started 1792), the Crinan Canal (1794) and the Kennet and Avon Canal (also started 1794).
Rennie died in London in 1821 and he was buried in St Paul's Cathedral. His final design project, London Bridge (1824-1831), was to be completed by his son, also known as John Rennie.
He built many bridges, canals, docks: