John Scott was born to William Henry and Anna Symmes Harrison on October 4, 1804 at Vincennes, Indiana. He studied medicine, but became a farmer. He was elected to Congress in 1852 as a Whig and in 1854 as a Republican. When he was defeated in 1856 he retired to his farm in Hamilton County, Ohio.
Harrison died on May 25, 1878 at his home near North Bend, Ohio and is buried in the Harrrison Tomb and monument there.
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