It is the long (multi-generational) story of the conflict between Joestar's family and Dio. The story begins from Dio's arrival in Joestar's family. Dio conspires to kill Joestar, but is discovered by Joestar's son Jonathan. The battle between Jonathan and Dio begins, and continues even to his child and grandchild.
Two OVA series have been made so far, totalling thirteen episodes.