She first came to national attention with a series of columns in The Independent. These were musings and reflections on family and on the everyday occurrences and fears of life. They often featured her husband, the playwright and producer Jonathan Myerson, and their young children Jacob, Chloe, and Raphael.
Her first novel was Sleepwalking (1994), and it was to some degree autobiographical, in that it deals with the suicide of an uncaring and abusive father. The main character Susan is heavily pregnant and begins an affair. She also feels she is haunted by his father's mother, reliving the neglect that made him abusive.
In The Touch (1996) a group of young people try to help a tramp who preaches fundamentalist Christianity, and who turns violently against them.
In Me and the Fat Man (1999) a waitress takes to earning extra money giving oral sex in a park; she gets involved with two other men, friends who have an awkward relationship and a secret between them that turns out to be related to her own birth.
Laura Blundy (2001) is set in the Victorian period, and Julie Myerson tries to bring out the freshness and modernity of the period as it would have appeared at the time.
Something Might Happen (2003) is about a murder in a Suffolk seaside town.