The original county seat was Trinidad, on the county's southwestern coast. In 1854 the county seat was moved to Crescent City, because of its larger population. But the western portion of the county was unrepresentative of the mining interests in the eastern portion of the county, and so, in 1856, the county seat was moved inland, to Orleans Bar.
In 1857, Del Norte County, including Crescent City, was split off from Klamath County.
The county's economy was never healthy. In 1874 it was finally abolished, divided into Siskiyou and Humboldt Counties.