It was founded in 1919 by William Andrews Clark, Jr with Walter Henry Rothwell as its conductor. It played its first concert in the same year, eleven days after its first rehearsal.
Subsequent principal conductors have included Artur Rodzinski (1929-33), Otto Klemperer (1933-39), Eduard van Beinum (1956-59), Zubin Mehta (1962-78), Carlo Maria Giulini (1978-84) and André Previn (1985-89). From 1992, Esa-Pekka Salonen has been its chief conductor.
Since its founding in 1919, the LA Philharmonic has played at least one concert a year in its "sister city", Santa Barbara, California, presented by the Community Arts Music Association (CAMA).