The story takes place from 1825 to 1830, when Orsinia is ruled by the Austrian empire. The hero is Itale Sorde, the son of the owner of an estate on a lake called Malafrena in a valley of the same name. Itale leaves the estate, against his father's will, to engage in nationalistic and revolutionary politics in the capital.
In many ways, Malafrena reads like a nineteenth-century novel, with its many detailed characters, its political movement and love-story subplots, its lack of the supernatural, and its settings that range from the mansions of the aristocracy to slums and prisons.