Animator Chuck Jones first introduced the odd duo in his 1952 film Feed the Kitty. In the short, Marc Antony adopts the interminably cute kitten only to receive a stern warning from his owner not to "bring one more thing into this house . . . not one single solitary thing!" Marc Antony is thus forced to go to all lengths to keep his new pet under wraps. Meanwhile, Pussyfoot's cat-killing curiosity gets her into mess after mess, which Marc Antony must, of course, rescue her from. Jones would largely repeat the scenario in 1953 with Kiss Me Cat, only this time Marc Antony tries to convince his owners that the kitten is a champion mouser so they will let him keep her.
In Feline Frame-Up (1954), Jones pitted Marc Antony against another of his lesser-known players, Claude Cat. The conniving Claude convinces the animals' stodgy master that Marc Antony is trying to eat Pussyfoot, eventually leading to the poor pooch being tossed into the streets. As Claude enjoys his new dog-free life, Marc Antony trades his brawn for brains as he makes various attempts to get back at the cat from outside the house (he eventually forces Claude to sign a confession admitting to his crimes, and in the end, it's Claude who must sleep in the street).
Jones gave Pussyfoot a solo short in 1957 with Go Fly a Kit, the story of an eagle who teaches the kitten how to fly. In 1958, Jones once again paired the cat and canine for one final film, Cat Feud. This time, Marc Antony must defend Pussyfoot (and her catfood) from a thieving interloper.
After this cartoon, Jones retired the pair. Since then, they have been largely forgotten, replaced by other characters such as Jones' later creations, Wile E. Coyote and Pepe le Pew. Pussyfoot has appeared in some recent Warner Bros. merchandising, however, and the pair have been featured in various Warner Bros. productions, such as a 1999 Looney Tunes comic book story called "Bringing Up Baby".