The name of the institution changed to Mississippi State College for Women in 1920. The name changed again in 1974 to Mississippi University for Women. The university is referred to by alumni and friends as "The W."
In 1982 the Supreme Court of the United States ordered the University to admit a male student to the nursing program.
MUW is located in in the Southside district of Columbus, Mississippi, between College Street, Seventh Avenue South, Eleventh Street South, and Fifteenth Street South.
A noted alumna of the W is author Eudora Welty, for whom the administration building is named.