Research on the effects of moderate drinking is in its early stages. No long term studies have been done and control groups would be difficult to establish because of the many variables. Given the current state of the research, an editorial concludes in the December 1997 issue of the Journal of the Royal Society of Medicine that the recommendation to be a moderate drinker is "not only meaningless but also irresponsible" given that the many obvious health hazards of alcohol outweigh "the benefits of alcohol [which] are small and ill-understood" particularly when so many other cardiovascular treatments are available.
The U.S. Department of Health & Human Services’ National Toxicology Program listed alcohol as a known carcinogen in 2000. The NTP profile report on alcohol states that incidences of cancer rise dramatically when alcohol is used in conjunction with tobacco, another known carcinogen.