After he graduated from Hogwarts, Scamander joined the Ministry of Magic in the Department for the Regulation and Control of Magical Creatures. After two years in the office of House-Elf Relocation, years he describes as "tedious in the extreme" he transferred to the Beast Division, where he was rapidly promoted due to his great knowledge of magical beasts.
He was almost solely responsible for the creation of the Werewolf Registry in 1947 and says he is proudest of the Ban of Experimental Breeding, passed in1965, which prevented the creation of new and untamable monster within Britain. Scamander's work in the Dragon Reasearch Restraint Bureau led to many reasearch trips during which he collected information which he published in a book: Fantastic Beasts and Where to Find Them now in its 52nd edition.
Now retired, he lives in Dorset with his wife Porpentina and their pet Kneazles: Hopppy, Milly and Mauler.